› 6smb

X-ray diffraction
2.04Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149968 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase JAK1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 301 amino acids
Theoretical weight: 34.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P23458 (Residues: 854-1154; Coverage: 26%)
Gene names: JAK1, JAK1A, JAK1B
Sequence domains: Protein tyrosine and serine/threonine kinase

Ligands and Environments

1 bound ligand:
Ligand LKQ 2 x LKQ
1 modified residue:
Ligand PTR 4 x PTR

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 42.553Å b: 171.567Å c: 44.383Å
α: 90° β: 94.09° γ: 90°
R-values:
R R work R free
0.224 0.221 0.265
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer.
Xue et al. (2023)
5 more

5 mentions without citation

Curcumin and Its Analogs in Non-Small Cell Lung Cancer Treatment: Challenges and Expectations.
Tang et al. (2022)
4 more