› 6srs

Electron Microscopy
4.6Å resolution

Structure of the Fanconi anaemia core subcomplex

Released:
DOI: 10.2210/pdb6srs/pdb
PDB entry 6srs coloured by chain, front view.
PDB entry 6srs coloured by chain, side view.
PDB entry 6srs coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
Structure of the Fanconi anaemia monoubiquitin ligase complex.
Shakeel S, Rajendra E, Alcón P, O'Reilly F, Chorev DS, Maslen S, Degliesposti G, Russo CJ, He S, Hill CH, Skehel JM, Scheres SHW, Patel KJ, Rappsilber J, Robinson CV, Passmore LA
Nature 575 234-237 (2019)
PMID: 31666700
Related structures: EMD-10294

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 38-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-167474 (preferred)
Entry contents:
18 distinct polypeptide molecules
Macromolecules (18 distinct):
Unassigned secondary structure elements (central region, proposed FANCB-FAAP100) Chains: A, a
Molecule details ›
Chains: A, a
Length: 76 amino acids
Theoretical weight: 6.49 KDa
Source organism: Gallus gallus
Expression system: Spodoptera frugiperda
Unassigned secondary structure elements (central region, proposed FANCB-FAAP100) Chains: B, b
Molecule details ›
Chains: B, b
Length: 25 amino acids
Theoretical weight: 2.15 KDa
Source organism: Gallus gallus
Expression system: Spodoptera frugiperda
Unassigned secondary structure elements (central region, proposed FANCB-FAAP100) Chains: C, c
Molecule details ›
Chains: C, c
Length: 30 amino acids
Theoretical weight: 2.57 KDa
Source organism: Gallus gallus
Expression system: Spodoptera frugiperda
Unassigned secondary structure elements (central region, proposed FANCB-FAAP100) Chains: D, d
Molecule details ›
Chains: D, d
Length: 23 amino acids
Theoretical weight: 1.98 KDa
Source organism: Gallus gallus
Expression system: Spodoptera frugiperda
Unassigned secondary structure elements (central region, proposed FANCB-FAAP100) Chains: E, e
Molecule details ›
Chains: E, e
Length: 9 amino acids
Theoretical weight: 784 Da
Source organism: Gallus gallus
Expression system: Spodoptera frugiperda
Unassigned secondary structure elements (central region, proposed FANCB-FAAP100) Chains: F, f
Molecule details ›
Chains: F, f
Length: 15 amino acids
Theoretical weight: 1.29 KDa
Source organism: Gallus gallus
Expression system: Spodoptera frugiperda
Unassigned secondary structure elements (central region, proposed FANCB-FAAP100) Chains: G, g
Molecule details ›
Chains: G, g
Length: 26 amino acids
Theoretical weight: 2.23 KDa
Source organism: Gallus gallus
Expression system: Spodoptera frugiperda
Unassigned secondary structure elements (central region, proposed FANCB-FAAP100) Chains: H, J, h, j
Molecule details ›
Chains: H, J, h, j
Length: 17 amino acids
Theoretical weight: 1.46 KDa
Source organism: Gallus gallus
Expression system: Spodoptera frugiperda
Unassigned secondary structure elements (central region, proposed FANCB-FAAP100) Chains: I, i
Molecule details ›
Chains: I, i
Length: 37 amino acids
Theoretical weight: 3.17 KDa
Source organism: Gallus gallus
Expression system: Spodoptera frugiperda
Unassigned secondary structure elements (central region, proposed FANCB-FAAP100) Chains: K, k
Molecule details ›
Chains: K, k
Length: 21 amino acids
Theoretical weight: 1.81 KDa
Source organism: Gallus gallus
Expression system: Spodoptera frugiperda
Unassigned secondary structure elements (central region, proposed FANCB-FAAP100) Chains: L, l
Molecule details ›
Chains: L, l
Length: 18 amino acids
Theoretical weight: 1.55 KDa
Source organism: Gallus gallus
Expression system: Spodoptera frugiperda
Unassigned secondary structure elements (proposed FANCB) Chains: M, m
Molecule details ›
Chains: M, m
Length: 120 amino acids
Theoretical weight: 10.23 KDa
Source organism: Gallus gallus
Expression system: Spodoptera frugiperda
Unassigned secondary structure elements (proposed FAAP100) Chains: N, n
Molecule details ›
Chains: N, n
Length: 43 amino acids
Theoretical weight: 3.68 KDa
Source organism: Gallus gallus
Expression system: Spodoptera frugiperda
Unassigned secondary structure elements (proposed FANCB) Chains: O, o
Molecule details ›
Chains: O, o
Length: 279 amino acids
Theoretical weight: 23.76 KDa
Source organism: Gallus gallus
Expression system: Spodoptera frugiperda
Unassigned secondary structure elements (proposed FAAP100) Chains: P, p
Molecule details ›
Chains: P, p
Length: 276 amino acids
Theoretical weight: 23.51 KDa
Source organism: Gallus gallus
Expression system: Spodoptera frugiperda
Unassigned secondary structure elements (proposed FANCG) Chains: R, r
Molecule details ›
Chains: R, r
Length: 285 amino acids
Theoretical weight: 24.27 KDa
Source organism: Gallus gallus
Expression system: Spodoptera frugiperda
Unassigned secondary structure elements (proposed FANCG) Chains: S, s
Molecule details ›
Chains: S, s
Length: 145 amino acids
Theoretical weight: 12.36 KDa
Source organism: Gallus gallus
Expression system: Spodoptera frugiperda
Fanconi anemia protein FANCL Chains: Q, q
Molecule details ›
Chains: Q, q
Length: 91 amino acids
Theoretical weight: 10.48 KDa
Source organism: Gallus gallus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q3MUH5 (Residues: 6-95; Coverage: 24%)
Gene name: FANCL
Sequence domains: FANCL UBC-like domain 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.6Å
Relevant EMDB volumes: EMD-10294
Expression system: Spodoptera frugiperda

Quick links

Citations

20 review citations

Fanconi anemia and the underlying causes of genomic instability.
Rageul et al. (2020)
19 more

2 mentions without citation

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Martin et al. (2022)
1 more