› 6sw3

X-ray diffraction
1.2Å resolution

Crystal structure of CREBBP bromodomain L1109W mutant

Released:
DOI: 10.2210/pdb6sw3/pdb
PDB entry 6sw3 coloured by chain, front view.
PDB entry 6sw3 coloured by chain, side view.
PDB entry 6sw3 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Faessler C, Bedi RK, Wiedmer L, Caflisch A

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-109987 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
histone acetyltransferase Chains: A, B
Molecule details ›
Chains: A, B
Length: 119 amino acids
Theoretical weight: 14.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: B4E3L4 (Residues: 694-810; Coverage: 10%)
Sequence domains: Bromodomain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P21
Unit cell:
a: 24.66Å b: 45.79Å c: 109.3Å
α: 90° β: 95.686° γ: 90°
R-values:
R R work R free
0.202 0.201 0.221
Expression system: Escherichia coli BL21(DE3)

Quick links