› 6sy1

X-ray diffraction
1.87Å resolution

Crystal structure of the human 2-oxoadipate dehydrogenase DHTKD1 (E1)

Released:
DOI: 10.2210/pdb6sy1/pdb
PDB entry 6sy1 coloured by chain, front view.
PDB entry 6sy1 coloured by chain, side view.
PDB entry 6sy1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure and interaction studies of human DHTKD1 provide insight into a mitochondrial megacomplex in lysine catabolism.
Bezerra GA, Foster WR, Bailey HJ, Hicks KG, Sauer SW, Dimitrov B, McCorvie TJ, Okun JG, Rutter J, Kölker S, Yue WW
IUCrJ 7 693-706 (2020)
PMID: 32695416

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188539 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
2-oxoadipate dehydrogenase complex component E1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 898 amino acids
Theoretical weight: 100.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96HY7 (Residues: 45-919; Coverage: 95%)
Gene names: DHTKD1, KIAA1630
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand TPP 2 x TPP
Ligand MG 3 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P1
Unit cell:
a: 78.55Å b: 81.22Å c: 86.9Å
α: 63.43° β: 76.96° γ: 72.06°
R-values:
R R work R free
0.192 0.19 0.23
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Mitochondrial transport and metabolism of the vitamin B-derived cofactors thiamine pyrophosphate, coenzyme A, FAD and NAD+ , and related diseases: A review.
Palmieri et al. (2022)
3 more

5 mentions without citation

Toward an Understanding of the Structural and Mechanistic Aspects of Protein-Protein Interactions in 2-Oxoacid Dehydrogenase Complexes.
Nemeria et al. (2021)
4 more