› 6t36

X-ray diffraction
1.86Å resolution

Crystal structure of the PTPN3 PDZ domain bound to the HBV core protein C-terminal peptide

Released:
DOI: 10.2210/pdb6t36/pdb
Model geometry
Fit model/data
PDB entry 6t36 coloured by chain, front view.
PDB entry 6t36 coloured by chain, side view.
PDB entry 6t36 coloured by chain, top view.
Source organisms:
Primary publication:
Molecular basis of the interaction of the human tyrosine phosphatase PTPN3 with the hepatitis B virus core protein.
Genera M, Quioc-Salomon B, Nourisson A, Colcombet-Cazenave B, Haouz A, Mechaly A, Matondo M, Duchateau M, König A, Windisch MP, Neuveut C, Wolff N, Caillet-Saguy C
OpenAccess logo Sci Rep 11 944 (2021)
PMID: 33441627

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-108604 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tyrosine-protein phosphatase non-receptor type 3 Chain: A
Molecule details ›
Chain: A
Length: 913 amino acids
Theoretical weight: 104.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P26045 (Residues: 1-913; Coverage: 100%)
Gene names: PTPH1, PTPN3
Sequence domains:
Capsid protein Chain: B
Molecule details ›
Chain: B
Length: 212 amino acids
Theoretical weight: 24.39 KDa
Source organism: Hepatitis B virus
Expression system: Not provided
UniProt:
  • Canonical: A8D6S6 (Residues: 1-212; Coverage: 100%)
Gene names: C, HBVgp4, PC, PreC/C
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand BR 1 x BR
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P3221
Unit cell:
a: 75.578Å b: 75.578Å c: 46.594Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.198 0.195 0.239
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

3 review citations

The Hepatitis B Virus Interactome: A Comprehensive Overview.
Van Damme et al. (2021)
2 more

2 mentions without citation

Molecular basis of the interaction of the human tyrosine phosphatase PTPN3 with the hepatitis B virus core protein.
Genera et al. (2021)
1 more