› 6t63

Electron Microscopy
3.8Å resolution

A model of the EIAV CA-SP hexamer (C2) from Gag-deltaMA tubes assembled at pH6

Released:
DOI: 10.2210/pdb6t63/pdb
PDB entry 6t63 coloured by chain, front view.
PDB entry 6t63 coloured by chain, side view.
PDB entry 6t63 coloured by chain, top view.
Source organism: Equine infectious anemia virus (CLONE 1369)
Primary publication:
Structures of immature EIAV Gag lattices reveal a conserved role for IP6 in lentivirus assembly.
Dick RA, Xu C, Morado DR, Kravchuk V, Ricana CL, Lyddon TD, Broad AM, Feathers JR, Johnson MC, Vogt VM, Perilla JR, Briggs JAG, Schur FKM
PLoS Pathog 16 e1008277 (2020)
PMID: 31986188
Related structures: EMD-10383

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo octadecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159646 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gag polyprotein Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R
Length: 486 amino acids
Theoretical weight: 54.88 KDa
Source organism: Equine infectious anemia virus (CLONE 1369)
Expression system: Escherichia coli
UniProt:
  • Canonical: P69730 (Residues: 1-486; Coverage: 100%)
Gene name: gag
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.8Å
Relevant EMDB volumes: EMD-10383
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Budding of a Retrovirus: Some Assemblies Required.
Rose et al. (2020)
10 more

2 mentions without citation

Electron microscopy holdings of the Protein Data Bank: the impact of the resolution revolution, new validation tools, and implications for the future.
Burley et al. (2022)
1 more