› 6t6f

X-ray diffraction
1.97Å resolution

Crystal structure of human calmodulin-dependent protein kinase 1D (CAMK1D) bound to compound 8 (CS275)

Released:
DOI: 10.2210/pdb6t6f/pdb
PDB entry 6t6f coloured by chain, front view.
PDB entry 6t6f coloured by chain, side view.
PDB entry 6t6f coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Sorrell F, Kraemer A, Butterworth S, Edwards AM, Arrowsmith CH, Bountra C, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184844 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium/calmodulin-dependent protein kinase type 1D Chains: A, B
Molecule details ›
Chains: A, B
Length: 322 amino acids
Theoretical weight: 36.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IU85 (Residues: 10-329; Coverage: 83%)
Gene names: CAMK1D, CAMKID
Sequence domains: Protein kinase domain

Ligands and Environments

1 bound ligand:
Ligand MMW 2 x MMW
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P21212
Unit cell:
a: 109.95Å b: 115.73Å c: 53.96Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.21 0.238
Expression system: Escherichia coli

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