› 6t8u

X-ray diffraction
2.84Å resolution

Function and Biology Details

Reaction catalysed: 
Cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg-|- bond in complement component C5 alpha-chain to yield C5a and C5b.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133303 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Complement factor B Bb Chains: AAA, BBB, CCC
Molecule details ›
Chains: AAA, BBB, CCC
Length: 291 amino acids
Theoretical weight: 32.96 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P00751 (Residues: 474-764; Coverage: 39%)
Gene names: BF, BFD, CFB
Sequence domains: Trypsin

Ligands and Environments

2 bound ligands:
Ligand MVZ 3 x MVZ
Ligand SO4 8 x SO4
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P43212
Unit cell:
a: 91.926Å b: 91.926Å c: 260.415Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.198 0.239
Expression system: Drosophila melanogaster

Quick links

Citations

9 review citations

Tipping the balance: intricate roles of the complement system in disease and therapy.
Pouw et al. (2021)
8 more