› 6t9r

X-ray diffraction
1.72Å resolution

Aplysia californica AChBP in complex with a cytisine derivative

Released:
DOI: 10.2210/pdb6t9r/pdb
Model geometry
Fit model/data
PDB entry 6t9r coloured by chain, front view.
PDB entry 6t9r coloured by chain, side view.
PDB entry 6t9r coloured by chain, top view.
Source organism: Aplysia californica
Primary publication:
The thermodynamic profile and molecular interactions of a C(9)-cytisine derivative-binding acetylcholine-binding protein from Aplysia californica.
Davis S, Rego Campello H, Gallagher T, Hunter WN
OpenAccess logo Acta Crystallogr F Struct Biol Commun 76 74-80 (2020)
PMID: 32039888

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186694 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neurotransmitter-gated ion-channel ligand-binding domain-containing protein Chains: AAA, BBB, CCC, DDD, EEE, FFF, GGG, HHH, III, JJJ
Molecule details ›
Chains: AAA, BBB, CCC, DDD, EEE, FFF, GGG, HHH, III, JJJ
Length: 249 amino acids
Theoretical weight: 28.33 KDa
Source organism: Aplysia californica
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q8WSF8 (Residues: 1-236; Coverage: 100%)
Sequence domains: Neurotransmitter-gated ion-channel ligand binding domain

Ligands and Environments

6 bound ligands:
Ligand MXQ 10 x MXQ
Ligand NAG 10 x NAG
Ligand GOL 41 x GOL
Ligand PO4 10 x PO4
Ligand CL 10 x CL
Ligand K 10 x K
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: C2
Unit cell:
a: 209.466Å b: 132.874Å c: 131.086Å
α: 90° β: 102.524° γ: 90°
R-values:
R R work R free
0.163 0.162 0.192
Expression system: Trichoplusia ni

Quick links

Citations

1 citations in other articles

Delineating the activity of the potent nicotinic acetylcholine receptor agonists (+)-anatoxin-a and (-)-hosieine-A.
Parker et al. (2022)

1 mention without citation

The thermodynamic profile and molecular interactions of a C(9)-cytisine derivative-binding acetylcholine-binding protein from Aplysia californica.
Davis et al. (2020)