› 6tc2

X-ray diffraction
1.36Å resolution

Monoclinic human insulin in complex with p-coumaric acid

Released:
DOI: 10.2210/pdb6tc2/pdb
Model geometry
Fit model/data
PDB entry 6tc2 coloured by chain, front view.
PDB entry 6tc2 coloured by chain, side view.
PDB entry 6tc2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Insulin polymorphism induced by two polyphenols: new crystal forms and advances in macromolecular powder diffraction.
Triandafillidis DP, Parthenios N, Spiliopoulou M, Valmas A, Kosinas C, Gozzo F, Reinle-Schmitt M, Beckers D, Degen T, Pop M, Fitch AN, Wollenhaupt J, Weiss MS, Karavassili F, Margiolaki I
Acta Crystallogr D Struct Biol 76 1065-1079 (2020)
PMID: 33135678

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134209 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Insulin Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 110 amino acids
Theoretical weight: 11.99 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P01308 (Residues: 1-110; Coverage: 100%)
Gene name: INS
Sequence domains: Insulin/IGF/Relaxin family

Ligands and Environments

4 bound ligands:
Ligand ZN 2 x ZN
Ligand PO4 3 x PO4
Ligand HC4 5 x HC4
Ligand SCN 1 x SCN
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P21
Unit cell:
a: 41Å b: 67.65Å c: 47.59Å
α: 90° β: 94.8° γ: 90°
R-values:
R R work R free
0.16 0.16 0.188
Expression system: Saccharomyces cerevisiae

Quick links

Citations

1 citations in other articles

The T2 structure of polycrystalline cubic human insulin.
Triandafillidis et al. (2023)