› 6tgy

Electron Microscopy
3.5Å resolution

Cryo-EM structure of p62-PB1 filament (L-type)

Released:
DOI: 10.2210/pdb6tgy/pdb
PDB entry 6tgy coloured by chain, front view.
PDB entry 6tgy coloured by chain, side view.
PDB entry 6tgy coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake.
Jakobi AJ, Huber ST, Mortensen SA, Schultz SW, Palara A, Kuhm T, Shrestha BK, Lamark T, Hagen WJH, Wilmanns M, Johansen T, Brech A, Sachse C
Nat Commun 11 440 (2020)
PMID: 31974402
Related structures: EMD-10501

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo 120-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171723 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sequestosome-1 Chain: A
Molecule details ›
Chain: A
Length: 122 amino acids
Theoretical weight: 13.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13501 (Residues: 1-122; Coverage: 28%)
Gene names: ORCA, OSIL, SQSTM1
Sequence domains: PB1 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-10501
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

12 review citations

Autophagy and liver cancer.
Chao et al. (2020)
11 more

3 mentions without citation

Recent Advances in Single-Particle Electron Microscopic Analysis of Autophagy Degradation Machinery.
Cheung et al. (2020)
2 more