› 6thg

X-ray diffraction
4.07Å resolution

Cedar Virus attachment glycoprotein (G) in complex with human ephrin-B1

Released:
DOI: 10.2210/pdb6thg/pdb
PDB entry 6thg coloured by chain, front view.
PDB entry 6thg coloured by chain, side view.
PDB entry 6thg coloured by chain, top view.
Source organisms:
Primary publication:
A key region of molecular specificity orchestrates unique ephrin-B1 utilization by Cedar virus.
Pryce R, Azarm K, Rissanen I, Harlos K, Bowden TA, Lee B
Life Sci Alliance 3 (2020)
PMID: 31862858

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-125334 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Attachment glycoprotein Chains: A, B, E, G, I
Molecule details ›
Chains: A, B, E, G, I
Length: 426 amino acids
Theoretical weight: 48.82 KDa
Source organism: Cedar virus
Expression system: Homo sapiens
UniProt:
  • Canonical: J7H333 (Residues: 209-622; Coverage: 67%)
Gene name: G
Sequence domains: Haemagglutinin-neuraminidase
Ephrin-B1 Chains: C, D, F, H, J
Molecule details ›
Chains: C, D, F, H, J
Length: 151 amino acids
Theoretical weight: 17.25 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P98172 (Residues: 29-167; Coverage: 44%)
Gene names: EFL3, EFNB1, EPLG2, LERK2
Sequence domains: Ephrin

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 17 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P212121
Unit cell:
a: 112.796Å b: 138.435Å c: 235.394Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.278 0.276 0.314
Expression system: Homo sapiens

Quick links

Citations

7 review citations

Receptor-mediated cell entry of paramyxoviruses: Mechanisms, and consequences for tropism and pathogenesis.
Navaratnarajah et al. (2020)
6 more

1 mention without citation

A key region of molecular specificity orchestrates unique ephrin-B1 utilization by Cedar virus.
Pryce et al. (2020)