› 6tod

X-ray diffraction
2.11Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129031 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Orexin/Hypocretin receptor type 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 336 amino acids
Theoretical weight: 38.16 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O43613 (Residues: 28-380; Coverage: 76%)
Gene name: HCRTR1
Sequence domains: 7 transmembrane receptor (rhodopsin family)

Ligands and Environments

7 bound ligands:
Ligand 7MA 2 x 7MA
Ligand SO4 3 x SO4
Ligand PG4 5 x PG4
Ligand CIT 1 x CIT
Ligand SOG 47 x SOG
Ligand PGW 2 x PGW
Ligand NA 2 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Unit cell:
a: 57.907Å b: 158.891Å c: 182.354Å
α: 90° β: 95.77° γ: 90°
R-values:
R R work R free
0.189 0.188 0.208
Expression system: Spodoptera frugiperda

Quick links

Citations

4 review citations

Put a ring on it: application of small aliphatic rings in medicinal chemistry.
Bauer et al. (2021)
3 more

5 mentions without citation

G protein-coupled receptors: structure- and function-based drug discovery.
Yang et al. (2021)
4 more