› 6tsz

X-ray diffraction
1.9Å resolution

The ULK4 Pseudokinase Domain Bound To ATPgammaS

Released:
DOI: 10.2210/pdb6tsz/pdb
PDB entry 6tsz coloured by chain, front view.
PDB entry 6tsz coloured by chain, side view.
PDB entry 6tsz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Nucleotide Binding, Evolutionary Insights, and Interaction Partners of the Pseudokinase Unc-51-like Kinase 4.
Preuss F, Chatterjee D, Mathea S, Shrestha S, St-Germain J, Saha M, Kannan N, Raught B, Rottapel R, Knapp S
Structure 28 1184-1196.e6 (2020)
PMID: 32814032

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188398 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase ULK4 Chain: U
Molecule details ›
Chain: U
Length: 305 amino acids
Theoretical weight: 34.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96C45 (Residues: 2-288; Coverage: 23%)
Gene name: ULK4
Sequence domains: Protein kinase domain

Ligands and Environments

1 bound ligand:
Ligand AGS 1 x AGS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 62.442Å b: 41.468Å c: 69.755Å
α: 90° β: 113.063° γ: 90°
R-values:
R R work R free
0.203 0.201 0.253
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Genome Instability in Multiple Myeloma: Facts and Factors.
Aksenova et al. (2021)
3 more

2 mentions without citation

There's more to death than life: Noncatalytic functions in kinase and pseudokinase signaling.
Mace et al. (2021)
1 more