6ttk

X-ray diffraction
2.38Å resolution

Crystal structure of the kelch domain of human KLHL12 in complex with DVL1 peptide

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Kelch-like protein 12 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 301 amino acids
Theoretical weight: 32.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q53G59 (Residues: 268-567; Coverage: 53%)
Gene names: C3IP1, KLHL12
Sequence domains: Kelch motif
Segment polarity protein dishevelled homolog DVL-1 Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 15 amino acids
Theoretical weight: 1.42 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O14640 (Residues: 650-664; Coverage: 2%)
Gene name: DVL1

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P21
Unit cell:
a: 80.225Å b: 73.145Å c: 101.845Å
α: 90° β: 94.5° γ: 90°
R-values:
R R work R free
0.227 0.225 0.251
Expression systems:
  • Escherichia coli
  • Not provided