Function and Biology Details
Reactions catalysed:
S-[NEDD8-protein]-yl-[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]-L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + N(6)-[NEDD8-protein]-yl-[cullin]-L-lysine
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine
(1a) S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [(E3-independent) E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-monoubiquitinyl-[(E3-independent) ubiquitin-conjugating enzyme]-L-cysteine
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero octamer (preferred)
PDBe Complex ID:
PDB-CPX-124769 (preferred)
Entry contents:
8 distinct polypeptide molecules
Macromolecules (8 distinct):
F-box/WD repeat-containing protein 1A
Molecule details ›
Q9Y297
S-phase kinase-associated protein 1
Molecule details ›
Cullin-1
Ubiquitin-like protein NEDD8
E3 ubiquitin-protein ligase RBX1
Ubiquitin-conjugating enzyme E2 D2
Ubiquitin
NF-kappa-B inhibitor alpha
