› 6tu4

Electron Microscopy
2.6Å resolution

Structure of Plasmodium Actin1 filament

Released:
DOI: 10.2210/pdb6tu4/pdb
PDB entry 6tu4 coloured by chain, front view.
PDB entry 6tu4 coloured by chain, side view.
PDB entry 6tu4 coloured by chain, top view.
Source organism: Plasmodium falciparum 3D7
Primary publication:
High-resolution structures of malaria parasite actomyosin and actin filaments.
Vahokoski J, Calder LJ, Lopez AJ, Molloy JE, Kursula I, Rosenthal PB
PLoS Pathog 18 e1010408 (2022)
PMID: 35377914
Related structures: EMD-10587

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184679 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Actin-1 Chains: A, B, C, D, F
Molecule details ›
Chains: A, B, C, D, F
Length: 378 amino acids
Theoretical weight: 42.05 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8I4X0 (Residues: 1-376; Coverage: 100%)
Gene names: ACT1, ACTI, PF3D7_1246200, PFL2215w
Sequence domains: Actin

Ligands and Environments

3 bound ligands:
Ligand MG 5 x MG
Ligand 9UE 5 x 9UE
Ligand ADP 5 x ADP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.6Å
Relevant EMDB volumes: EMD-10587
Expression system: Spodoptera frugiperda

Quick links

Citations

6 citation in other articles

High-resolution structures of the actomyosin-V complex in three nucleotide states provide insights into the force generation mechanism.
Pospich et al. (2021)
5 more

3 mentions without citation

High-resolution structures of malaria parasite actomyosin and actin filaments.
Vahokoski et al. (2022)
2 more