› 6txz

X-ray diffraction
3.06Å resolution

FAB PART OF M6903 IN COMPLEX WITH HUMAN TIM3

Released:
DOI: 10.2210/pdb6txz/pdb
PDB entry 6txz coloured by chain, front view.
PDB entry 6txz coloured by chain, side view.
PDB entry 6txz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Identification and characterization of M6903, an antagonistic anti-TIM-3 monoclonal antibody.
Zhang D, Jiang F, Zaynagetdinov R, Huang H, Sood VD, Wang H, Zhao X, Jenkins MH, Ji Q, Wang Y, Nannemann DP, Musil D, Wesolowski J, Paoletti A, Bartholomew T, Derner MG, An Q, Iffland C, Halle JP
Oncoimmunology 9 1744921 (2020)
PMID: 32313722

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-212636 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Hepatitis A virus cellular receptor 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 110 amino acids
Theoretical weight: 12.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8TDQ0 (Residues: 22-130; Coverage: 39%)
Gene names: HAVCR2, TIM3, TIMD3
Sequence domains: Immunoglobulin V-set domain
Fab H Chains: H, I, J, K
Molecule details ›
Chains: H, I, J, K
Length: 229 amino acids
Theoretical weight: 24.22 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Fab L Chains: L, M, N, O
Molecule details ›
Chains: L, M, N, O
Length: 214 amino acids
Theoretical weight: 22.55 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 12.3.1
Spacegroup: C2221
Unit cell:
a: 119.35Å b: 270.115Å c: 197.889Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.197 0.253
Expression systems:
  • Escherichia coli
  • Homo sapiens

Quick links

Citations

8 review citations

Immune checkpoint inhibition for pancreatic ductal adenocarcinoma: limitations and prospects: a systematic review.
Li et al. (2021)
7 more

2 mentions without citation

Phosphatidylserine binding directly regulates TIM-3 function.
Smith et al. (2021)
1 more