› 6tys

Electron Microscopy
3.5Å resolution

A potent cross-neutralizing antibody targeting the fusion glycoprotein inhibits Nipah virus and Hendra virus infection

Released:
DOI: 10.2210/pdb6tys/pdb
PDB entry 6tys coloured by chain, front view.
PDB entry 6tys coloured by chain, side view.
PDB entry 6tys coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
An antibody against the F glycoprotein inhibits Nipah and Hendra virus infections.
Dang HV, Chan YP, Park YJ, Snijder J, Da Silva SC, Vu B, Yan L, Feng YR, Rockx B, Geisbert TW, Mire CE, Broder CC, Veesler D
Nat Struct Mol Biol 26 980-987 (2019)
PMID: 31570878
Related structures: EMD-20584

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero nonamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-212747 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (6 distinct):
Fusion glycoprotein F0 Chains: A, B, E
Molecule details ›
Chains: A, B, E
Length: 538 amino acids
Theoretical weight: 59.7 KDa
UniProt:
  • Canonical: Q9IH63 (Residues: 1-104, 105-495; Coverage: 90%)
Gene name: F
Sequence domains: Fusion glycoprotein F0
5B3 antibody heavy chain Chains: C, F, H
Molecule details ›
Chains: C, F, H
Length: 120 amino acids
Theoretical weight: 13.25 KDa
Source organism: Mus musculus
Expression system: Mus musculus
5B3 antibody light chain Chains: D, G, L
Molecule details ›
Chains: D, G, L
Length: 107 amino acids
Theoretical weight: 11.52 KDa
Source organism: Mus musculus
Expression system: Mus musculus

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: MAN, BMA
Carbohydrate polymer
1 bound ligand:
Ligand NAG 6 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-20584
Expression system: Mus musculus

Quick links

Citations

11 review citations

Principles and practical applications of structure-based vaccine design.
Byrne et al. (2022)
10 more

10 mentions without citation

Are we ready to fight the Nipah virus pandemic? An overview of drug targets, current medications, and potential leads.
Yang et al. (2023)
9 more