Function and Biology Details
Reactions catalysed:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- EF-hand domain
- Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
- EF-Hand 1, calcium-binding site
- FKBP-type peptidyl-prolyl cis-trans isomerase domain
- Metallo-dependent phosphatase-like
- Peptidyl-prolyl cis-trans isomerase domain superfamily
- EF-hand domain pair
- Calcineurin B protein
4 more domains
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-111417 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Serine/threonine-protein phosphatase
Molecule details ›
Chains: A, D
Length: 411 amino acids
Theoretical weight: 47.25 KDa
Source organism: Candida albicans WO-1
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: Calcineurin-like phosphoesterase
Length: 411 amino acids
Theoretical weight: 47.25 KDa
Source organism: Candida albicans WO-1
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
C4YFI3 (Residues: 54-445; Coverage: 64%)
Sequence domains: Calcineurin-like phosphoesterase
Calcineurin subunit B
Molecule details ›
Chains: B, E
Length: 173 amino acids
Theoretical weight: 19.45 KDa
Source organism: Candida albicans WO-1
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: EF-hand domain pair
Length: 173 amino acids
Theoretical weight: 19.45 KDa
Source organism: Candida albicans WO-1
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical: C4YS24 (Residues: 1-173; Coverage: 100%)
Sequence domains: EF-hand domain pair
FK506-binding protein 1
Molecule details ›
Chains: C, F
Length: 127 amino acids
Theoretical weight: 13.56 KDa
Source organism: Candida albicans SC5314
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: FKBP-type peptidyl-prolyl cis-trans isomerase
Length: 127 amino acids
Theoretical weight: 13.56 KDa
Source organism: Candida albicans SC5314
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical: P28870 (Residues: 1-124; Coverage: 100%)
Sequence domains: FKBP-type peptidyl-prolyl cis-trans isomerase
