› 6u07

X-ray diffraction
1.76Å resolution

Computational Stabilization of T Cell Receptor Constant Domains

Released:
DOI: 10.2210/pdb6u07/pdb
PDB entry 6u07 coloured by chain, front view.
PDB entry 6u07 coloured by chain, side view.
PDB entry 6u07 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Computational stabilization of T cell receptors allows pairing with antibodies to form bispecifics.
Froning K, Maguire J, Sereno A, Huang F, Chang S, Weichert K, Frommelt AJ, Dong J, Wu X, Austin H, Conner EM, Fitchett JR, Heng AR, Balasubramaniam D, Hilgers MT, Kuhlman B, Demarest SJ
Nat Commun 11 2330 (2020)
PMID: 32393818

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-125602 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ig-like domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 106 amino acids
Theoretical weight: 12.07 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q2YD82 (Residues: 100-195; Coverage: 40%)
Gene name: TRA@
Sequence domains: Domain of unknown function (DUF1968)
Ig-like domain-containing protein Chain: B
Molecule details ›
Chain: B
Length: 131 amino acids
Theoretical weight: 14.95 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: K7N5M4 (Residues: 120-249; Coverage: 50%)
Gene names: B2M, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain

Ligands and Environments

1 bound ligand:
Ligand MG 3 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: C2
Unit cell:
a: 96.854Å b: 59.852Å c: 61.352Å
α: 90° β: 110.24° γ: 90°
R-values:
R R work R free
0.203 0.202 0.226
Expression system: Cricetulus griseus

Quick links

Citations

4 review citations

Emerging new therapeutic antibody derivatives for cancer treatment.
Jin et al. (2022)
3 more

1 mention without citation

Computational stabilization of T cell receptors allows pairing with antibodies to form bispecifics.
Froning et al. (2020)