› 6u26

X-ray diffraction
1.53Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185468 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Proprotein convertase subtilisin/kexin type 9 Chains: A, B
Molecule details ›
Chains: A, B
Length: 707 amino acids
Theoretical weight: 76.08 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8NBP7 (Residues: 31-692; Coverage: 100%)
Gene names: NARC1, PCSK9, PSEC0052
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand 063 1 x 063
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P212121
Unit cell:
a: 62.68Å b: 70.92Å c: 150.12Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.187 0.213
Expression system: Homo sapiens

Quick links

Citations

4 review citations

The Potential of Proteolytic Chimeras as Pharmacological Tools and Therapeutic Agents.
Coll-Martínez et al. (2020)
3 more

5 mentions without citation

PCSK9 as a Target for Development of a New Generation of Hypolipidemic Drugs.
Kuzmich et al. (2022)
4 more