› 6u5l

X-ray diffraction
1.75Å resolution

Structure of human ULK4 in complex with an inhibitor

Released:
DOI: 10.2210/pdb6u5l/pdb
PDB entry 6u5l coloured by chain, front view.
PDB entry 6u5l coloured by chain, side view.
PDB entry 6u5l coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
High-Resolution Structure and Inhibition of the Schizophrenia-Linked Pseudokinase ULK4.
Khamrui S, Ung PMU, Secor C, Schlessinger A, Lazarus MB
J Am Chem Soc 142 33-37 (2020)
PMID: 31841327

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188398 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase ULK4 Chain: A
Molecule details ›
Chain: A
Length: 287 amino acids
Theoretical weight: 32.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96C45 (Residues: 1-285; Coverage: 22%)
Gene name: ULK4
Sequence domains: Protein kinase domain

Ligands and Environments

3 bound ligands:
Ligand 3RJ 1 x 3RJ
Ligand GOL 4 x GOL
Ligand PEG 1 x PEG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P6522
Unit cell:
a: 90.421Å b: 90.421Å c: 188.956Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.192 0.191 0.216
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

There's more to death than life: Noncatalytic functions in kinase and pseudokinase signaling.
Mace et al. (2021)
4 more

1 mention without citation

Computational tools and resources for pseudokinase research.
O'Boyle et al. (2022)