› 6u66

X-ray diffraction
0.99Å resolution

Structure of the trimeric globular domain of Adiponectin

Released:
DOI: 10.2210/pdb6u66/pdb
PDB entry 6u66 coloured by chain, front view.
PDB entry 6u66 coloured by chain, side view.
PDB entry 6u66 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Mapping and engineering the interaction between adiponectin and T-cadherin.
Pascolutti R, Erlandson SC, Burri DJ, Zheng S, Kruse AC
J Biol Chem 295 2749-2759 (2020)
PMID: 31915248

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172431 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adiponectin Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 142 amino acids
Theoretical weight: 16.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q15848 (Residues: 107-244; Coverage: 61%)
Gene names: ACDC, ACRP30, ADIPOQ, APM1, GBP28
Sequence domains: C1q domain

Ligands and Environments

2 bound ligands:
Ligand CA 3 x CA
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P1
Unit cell:
a: 47.923Å b: 49.635Å c: 50.306Å
α: 116.83° β: 100.89° γ: 104.92°
R-values:
R R work R free
0.166 0.165 0.19
Expression system: Escherichia coli BL21

Quick links

Citations

6 review citations

The Complex Roles of Adipokines in Polycystic Ovary Syndrome and Endometriosis.
Schüler-Toprak et al. (2022)
5 more

4 mentions without citation

Adiponectin Deregulation in Systemic Autoimmune Rheumatic Diseases.
Brezovec et al. (2021)
3 more