› 6ucm

X-ray diffraction
2.42Å resolution

Transcription factor DeltaFosB bZIP domain self-assembly, type-II crystal

Released:
DOI: 10.2210/pdb6ucm/pdb
PDB entry 6ucm coloured by chain, front view.
PDB entry 6ucm coloured by chain, side view.
PDB entry 6ucm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Self-assembly of the bZIP transcription factor ΔFosB.
Yin Z, Venkannagari H, Lynch H, Aglyamova G, Bhandari M, Machius M, Nestler EJ, Robison AJ, Rudenko G
Curr Res Struct Biol 2 1-13 (2020)
PMID: 32542236

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156805 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein FosB Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 68 amino acids
Theoretical weight: 8.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P53539 (Residues: 153-219; Coverage: 20%)
Gene names: FOSB, G0S3
Sequence domains: bZIP transcription factor

Ligands and Environments

2 bound ligands:
Ligand EDO 6 x EDO
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P3221
Unit cell:
a: 101.925Å b: 101.925Å c: 51.347Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.212 0.208 0.245
Expression system: Escherichia coli

Quick links

Citations

1 citations in other articles

ΔFOSB: A Potentially Druggable Master Orchestrator of Activity-Dependent Gene Expression.
Robison et al. (2022)

1 mention without citation

Self-assembly of the bZIP transcription factor ΔFosB.
Yin et al. (2020)