› 6uei

X-ray diffraction
2.51Å resolution

Crystal structure of human zinc finger antiviral protein

Released:
DOI: 10.2210/pdb6uei/pdb
PDB entry 6uei coloured by chain, front view.
PDB entry 6uei coloured by chain, side view.
PDB entry 6uei coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the zinc-finger antiviral protein in complex with RNA reveals a mechanism for selective targeting of CG-rich viral sequences.
Meagher JL, Takata M, Gonçalves-Carneiro D, Keane SC, Rebendenne A, Ong H, Orr VK, MacDonald MR, Stuckey JA, Bieniasz PD, Smith JL
Proc Natl Acad Sci U S A 116 24303-24309 (2019)
PMID: 31719195

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-182240 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Zinc finger CCCH-type antiviral protein 1 Chain: A
Molecule details ›
Chain: A
Length: 229 amino acids
Theoretical weight: 25.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7Z2W4 (Residues: 2-227; Coverage: 25%)
Gene names: PRO1677, ZC3HAV1, ZC3HDC2
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand ZN 4 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P65
Unit cell:
a: 124.35Å b: 124.35Å c: 43.04Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.208 0.206 0.244
Expression system: Escherichia coli

Quick links

Citations

26 review citations

The Potential Intermediate Hosts for SARS-CoV-2.
Zhao et al. (2020)
25 more

4 mentions without citation

Structure of the zinc-finger antiviral protein in complex with RNA reveals a mechanism for selective targeting of CG-rich viral sequences.
Meagher et al. (2019)
3 more