› 6ugw

X-ray diffraction
2Å resolution

Crystal structure of the Fc fragment of PF06438179/GP1111 an infliximab biosimilar in a C-centered orthorhombic crystal form, Lot A

Released:
DOI: 10.2210/pdb6ugw/pdb
PDB entry 6ugw coloured by chain, front view.
PDB entry 6ugw coloured by chain, side view.
PDB entry 6ugw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal Structures of PF-06438179/GP1111, an Infliximab Biosimilar.
Lerch TF, Sharpe P, Mayclin SJ, Edwards TE, Polleck S, Rouse JC, Zou Q, Conlon HD
BioDrugs 34 77-87 (2020)
PMID: 31650490

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-143689 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Immunoglobulin gamma-1 heavy chain Chain: A
Molecule details ›
Chain: A
Length: 255 amino acids
Theoretical weight: 28.36 KDa
Source organism: Homo sapiens
Expression system: Mus musculus
UniProt:
  • Canonical: P0DOX5 (Residues: 211-449; Coverage: 53%)
Sequence domains: Immunoglobulin C1-set domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN, GAL, FUC
Carbohydrate polymer
2 bound ligands:
Ligand ZN 3 x ZN
Ligand ACT 1 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: C2221
Unit cell:
a: 50.09Å b: 148.09Å c: 75.79Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.182 0.181 0.219
Expression system: Mus musculus

Quick links

Citations

1 review citation

Analytical Similarity Assessment of Biosimilars: Global Regulatory Landscape, Recent Studies and Major Advancements in Orthogonal Platforms.
Nupur et al. (2022)
1 other article

1 mention without citation

Crystal Structures of PF-06438179/GP1111, an Infliximab Biosimilar.
Lerch et al. (2020)