› 6uiv

Electron Microscopy
3.3Å resolution

Cryo-EM structure of human CALHM2 in an active/open state

Released:
DOI: 10.2210/pdb6uiv/pdb
PDB entry 6uiv coloured by chain, front view.
PDB entry 6uiv coloured by chain, side view.
PDB entry 6uiv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structures and gating mechanism of human calcium homeostasis modulator 2.
Choi W, Clemente N, Sun W, Du J, Lü W
Nature 576 163-167 (2019)
PMID: 31776515
Related structures: EMD-20788

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo undecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190711 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium homeostasis modulator protein 2 Chains: A, B, C, D, E, F, G, H, I, J, K
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K
Length: 331 amino acids
Theoretical weight: 37.2 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9HA72 (Residues: 1-323; Coverage: 100%)
Gene names: CALHM2, FAM26B
Sequence domains: Calcium homeostasis modulator

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-20788
Expression system: Homo sapiens

Quick links

Citations

7 review citations

Taste transduction and channel synapses in taste buds.
Taruno et al. (2021)
6 more

3 mentions without citation

The structures and gating mechanism of human calcium homeostasis modulator 2.
Choi et al. (2019)
2 more