› 6uiw

Electron Microscopy
2.7Å resolution

Cryo-EM structure of human CALHM2 in a ruthenium red-bound inhibited state

Released:
DOI: 10.2210/pdb6uiw/pdb
PDB entry 6uiw coloured by chain, front view.
PDB entry 6uiw coloured by chain, side view.
PDB entry 6uiw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structures and gating mechanism of human calcium homeostasis modulator 2.
Choi W, Clemente N, Sun W, Du J, Lü W
Nature 576 163-167 (2019)
PMID: 31776515
Related structures: EMD-20789

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo undecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190711 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium homeostasis modulator protein 2 Chains: A, B, C, D, E, F, G, H, I, J, K
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K
Length: 331 amino acids
Theoretical weight: 37.2 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9HA72 (Residues: 1-323; Coverage: 100%)
Gene names: CALHM2, FAM26B
Sequence domains: Calcium homeostasis modulator

Ligands and Environments

1 bound ligand:
Ligand R2R 11 x R2R
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.7Å
Relevant EMDB volumes: EMD-20789
Expression system: Homo sapiens

Quick links

Citations

6 review citations

Taste transduction and channel synapses in taste buds.
Taruno et al. (2021)
5 more

5 mentions without citation

On the molecular nature of large-pore channels.
Syrjanen et al. (2021)
4 more