› 6umu

X-ray diffraction
1.18Å resolution

Human apo PD-1 triple mutant

Released:
DOI: 10.2210/pdb6umu/pdb
PDB entry 6umu coloured by chain, front view.
PDB entry 6umu coloured by chain, side view.
PDB entry 6umu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A high-affinity human PD-1/PD-L2 complex informs avenues for small-molecule immune checkpoint drug discovery.
Tang S, Kim PS
Proc Natl Acad Sci U S A 116 24500-24506 (2019)
PMID: 31727844

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172197 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Programmed cell death protein 1 Chain: A
Molecule details ›
Chain: A
Length: 129 amino acids
Theoretical weight: 14.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15116 (Residues: 33-150; Coverage: 45%)
Gene names: PD1, PDCD1
Sequence domains: Immunoglobulin V-set domain

Ligands and Environments

1 bound ligand:
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P3221
Unit cell:
a: 46.172Å b: 46.172Å c: 89.27Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.154 0.154 0.164
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Immunotherapy in Treating EGFR-Mutant Lung Cancer: Current Challenges and New Strategies.
To et al. (2021)
4 more

1 mention without citation

A high-affinity human PD-1/PD-L2 complex informs avenues for small-molecule immune checkpoint drug discovery.
Tang et al. (2019)