› 6usc

X-ray diffraction
1.59Å resolution

Structure of Human Intelectin-1 in complex with KO

Released:
DOI: 10.2210/pdb6usc/pdb
PDB entry 6usc coloured by chain, front view.
PDB entry 6usc coloured by chain, side view.
PDB entry 6usc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Stereoelectronic Effects Impact Glycan Recognition.
McMahon CM, Isabella CR, Windsor IW, Kosma P, Raines RT, Kiessling LL
J Am Chem Soc 142 2386-2395 (2020)
PMID: 31930911

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186749 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Intelectin-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 279 amino acids
Theoretical weight: 31.06 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8WWA0 (Residues: 35-313; Coverage: 95%)
Gene names: INTL, ITLN, ITLN1, LFR, UNQ640/PRO1270

Ligands and Environments

3 bound ligands:
Ligand CA 6 x CA
Ligand KO2 2 x KO2
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P213
Unit cell:
a: 118.145Å b: 118.145Å c: 118.145Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.159 0.158 0.182
Expression system: Homo sapiens

Quick links

Citations

5 review citations

Conformational Studies of Oligosaccharides.
Yu et al. (2020)
4 more

2 mentions without citation

3D Structural View of Pathogen Recognition by Mammalian Lectin Receptors.
Manabe et al. (2021)
1 more