Function and Biology Details
Reactions catalysed:
S-adenosyl-L-methionine + a 5'-(5'-triphosphoguanosine)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA]
S-adenosyl-L-methionine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-[mRNA]
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Selective hydrolysis of -Xaa-Xaa-|-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala.
NTP + H(2)O = NDP + phosphate
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
- SH2 domain
- SH2 domain superfamily
- STAT transcription factor, protein interaction
- STAT transcription factor, N-terminal domain superfamily
- RNA-directed RNA polymerase, thumb subdomain, flavivirus
- RNA-directed RNA polymerase, catalytic domain
- RNA-dependent RNA polymerase, flavivirus
- DNA/RNA polymerase superfamily
8 more domains
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156585 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Signal transducer and activator of transcription 2
Molecule details ›
Chain: A
Length: 713 amino acids
Theoretical weight: 82.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains:
Length: 713 amino acids
Theoretical weight: 82.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
P52630 (Residues: 1-713; Coverage: 84%)
Sequence domains:
RNA-directed RNA polymerase NS5
Molecule details ›
Chain: B
Length: 631 amino acids
Theoretical weight: 73.16 KDa
Source organism: Zika virus
Expression system: Escherichia coli BL21(DE3)
UniProt:
Length: 631 amino acids
Theoretical weight: 73.16 KDa
Source organism: Zika virus
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical: Q32ZE1 (Residues: 2789-3419; Coverage: 19%)
