› 6v02

X-ray diffraction
2.46Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145907 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cation-independent mannose-6-phosphate receptor Chain: A
Molecule details ›
Chain: A
Length: 731 amino acids
Theoretical weight: 81.2 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P11717 (Residues: 43-763; Coverage: 29%)
Gene names: IGF2R, MPRI
Sequence domains: Cation-independent mannose-6-phosphate receptor repeat

Ligands and Environments

1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21
Unit cell:
a: 50.78Å b: 66.22Å c: 124.53Å
α: 90° β: 100.53° γ: 90°
R-values:
R R work R free
0.244 0.24 0.308
Expression system: Spodoptera frugiperda

Quick links

Citations

1 review citation

Mechanisms regulating the sorting of soluble lysosomal proteins.
Meraş et al. (2022)
12 other articles

1 mention without citation

Allosteric regulation of lysosomal enzyme recognition by the cation-independent mannose 6-phosphate receptor.
Olson et al. (2020)