› 6v03

Electron Microscopy
3.3Å resolution

ELIC-propylammonium complex in POPC-only nanodiscs

Released:
DOI: 10.2210/pdb6v03/pdb
PDB entry 6v03 coloured by chain, front view.
PDB entry 6v03 coloured by chain, side view.
PDB entry 6v03 coloured by chain, top view.
Source organism: Dickeya dadantii 3937
Primary publication:
Cryo-EM structures of a lipid-sensitive pentameric ligand-gated ion channel embedded in a phosphatidylcholine-only bilayer.
Kumar P, Wang Y, Zhang Z, Zhao Z, Cymes GD, Tajkhorshid E, Grosman C
Proc Natl Acad Sci U S A 117 1788-1798 (2020)
PMID: 31911476
Related structures: EMD-20968

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-122692 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neurotransmitter-gated ion-channel ligand-binding domain-containing protein Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 320 amino acids
Theoretical weight: 36.66 KDa
Source organism: Dickeya dadantii 3937
Expression system: Escherichia coli
UniProt:
  • Canonical: E0SJQ4 (Residues: 22-341; Coverage: 99%)
Gene name: Dda3937_00520
Sequence domains: Neurotransmitter-gated ion-channel ligand binding domain

Ligands and Environments

1 bound ligand:
Ligand 3CN 10 x 3CN
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-20968
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Ion channels as lipid sensors: from structures to mechanisms.
Thompson et al. (2020)
4 more

4 mentions without citation

Cryo-EM structures of a lipid-sensitive pentameric ligand-gated ion channel embedded in a phosphatidylcholine-only bilayer.
Kumar et al. (2020)
3 more