› 6v0s

X-ray diffraction
2.4Å resolution

Crystal structure of the bromodomain of human BRD9 bound to TG003

Released:
DOI: 10.2210/pdb6v0s/pdb
PDB entry 6v0s coloured by chain, front view.
PDB entry 6v0s coloured by chain, side view.
PDB entry 6v0s coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains.
Karim RM, Chan A, Zhu JY, Schönbrunn E
J Med Chem 63 3227-3237 (2020)
PMID: 32091206

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190677 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 9 Chains: A, B
Molecule details ›
Chains: A, B
Length: 123 amino acids
Theoretical weight: 14.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9H8M2 (Residues: 134-243; Coverage: 18%)
Gene names: BRD9, UNQ3040/PRO9856
Sequence domains: Bromodomain

Ligands and Environments

1 bound ligand:
Ligand EAE 2 x EAE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P21212
Unit cell:
a: 74.634Å b: 123.013Å c: 31.693Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.192 0.23
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

Exploiting vulnerabilities of SWI/SNF chromatin remodelling complexes for cancer therapy.
Wanior et al. (2021)
4 more

2 mentions without citation

Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains.
Karim et al. (2020)
1 more