› 6v0t

X-ray diffraction
2.1Å resolution

Crystal Structure of Catalytic Subunit of Bovine Pyruvate Dehydrogenase Phosphatase 1 - Catalytic Domain

Released:
DOI: 10.2210/pdb6v0t/pdb
PDB entry 6v0t coloured by chain, front view.
PDB entry 6v0t coloured by chain, side view.
PDB entry 6v0t coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Crystal structure of the catalytic subunit of bovine pyruvate dehydrogenase phosphatase.
Guo Y, Qiu W, Roche TE, Hackert ML
Acta Crystallogr F Struct Biol Commun 76 292-301 (2020)
PMID: 32627744

Function and Biology Details

Reaction catalysed: 
[Pyruvate dehydrogenase (acetyl-transferring)] phosphate + H(2)O = [pyruvate dehydrogenase (acetyl-transferring)] + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153031 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 467 amino acids
Theoretical weight: 52.68 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P35816 (Residues: 72-538; Coverage: 87%)
Gene names: PDP, PDP1, PPM2C
Sequence domains: Protein phosphatase 2C

Ligands and Environments

2 bound ligands:
Ligand MN 5 x MN
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P3221
Unit cell:
a: 75.339Å b: 75.339Å c: 173.255Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.221 0.219 0.247

Quick links

Citations

1 citations in other articles

α-Lipoic Acid Targeting PDK1/NRF2 Axis Contributes to the Apoptosis Effect of Lung Cancer Cells.
Yue et al. (2021)

1 mention without citation

Crystal structure of the catalytic subunit of bovine pyruvate dehydrogenase phosphatase.
Guo et al. (2020)