6v15

X-ray diffraction
2.8Å resolution

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-231695 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
HLA class II histocompatibility antigen, DR alpha chain Chain: A
Molecule details ›
Chain: A
Length: 189 amino acids
Theoretical weight: 21.92 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01903 (Residues: 30-206; Coverage: 77%)
Gene names: HLA-DRA, HLA-DRA1
Sequence domains:
HLA class II histocompatibility antigen, DRB1 beta chain Chain: B
Molecule details ›
Chain: B
Length: 198 amino acids
Theoretical weight: 23.08 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01911 (Residues: 30-219; Coverage: 80%)
Gene name: HLA-DRB1
Sequence domains:
Fibrinogen beta chain Chain: C
Molecule details ›
Chain: C
Length: 13 amino acids
Theoretical weight: 1.29 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P02675 (Residues: 69-81; Coverage: 3%)
Gene name: FGB
G08 TCR alpha chain Chain: D
Molecule details ›
Chain: D
Length: 206 amino acids
Theoretical weight: 22.74 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
G08 TCR beta chain Chain: E
Molecule details ›
Chain: E
Length: 241 amino acids
Theoretical weight: 27.48 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)

Ligands and Environments

2 bound ligands:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: C2
Unit cell:
a: 149.995Å b: 56.548Å c: 136.198Å
α: 90° β: 92.205° γ: 90°
R-values:
R R work R free
0.199 0.197 0.233
Expression systems:
  • Homo sapiens
  • Not provided
  • Escherichia coli BL21(DE3)