› 6v4e

X-ray diffraction
1.62Å resolution

Crystal Structure Analysis of Zebra Fish MDM

Released:
DOI: 10.2210/pdb6v4e/pdb
PDB entry 6v4e coloured by chain, front view.
PDB entry 6v4e coloured by chain, side view.
PDB entry 6v4e coloured by chain, top view.
Source organisms:
Primary publication:
Identification of a Structural Determinant for Selective Targeting of HDMX.
Ben-Nun Y, Seo HS, Harvey EP, Hauseman ZJ, Wales TE, Newman CE, Cathcart AM, Engen JR, Dhe-Paganon S, Walensky LD
Structure 28 847-857.e5 (2020)
PMID: 32359398

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-167592 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protein Mdm4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 104 amino acids
Theoretical weight: 12.13 KDa
Source organism: Danio rerio
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7ZUW7 (Residues: 15-106; Coverage: 19%)
Gene names: mdm4, mdmx
Sequence domains: SWIB/MDM2 domain
Stapled peptide QSQQTF(0EH)NLWRLL(MK8)QN(NH2) Chains: C, D
Molecule details ›
Chains: C, D
Length: 17 amino acids
Theoretical weight: 2.07 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MK8 2 x MK8

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P21
Unit cell:
a: 66.95Å b: 30.72Å c: 69.26Å
α: 90° β: 106.89° γ: 90°
R-values:
R R work R free
0.162 0.16 0.198
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

1 mention without citation

Identification of a Structural Determinant for Selective Targeting of HDMX.
Ben-Nun et al. (2020)