› 6v9g

X-ray diffraction
2.35Å resolution

Kindlin-3 double deletion mutant long form

Released:
DOI: 10.2210/pdb6v9g/pdb
PDB entry 6v9g coloured by chain, front view.
PDB entry 6v9g coloured by chain, side view.
PDB entry 6v9g coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure basis of the FERM domain of kindlin-3 in supporting integrin αIIbβ3 activation in platelets.
Sun J, Xiao D, Ni Y, Zhang T, Cao Z, Xu Z, Nguyen H, Zhang J, White GC, Ding J, Ma YQ, Xu Z
Blood Adv 4 3128-3135 (2020)
PMID: 32649767

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183195 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fermitin family homolog 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 492 amino acids
Theoretical weight: 56.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86UX7 (Residues: 1-667; Coverage: 73%)
Gene names: FERMT3, KIND3, MIG2B, URP2
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P212121
Unit cell:
a: 67.728Å b: 129.171Å c: 134.554Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.214 0.245
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Initiation of focal adhesion assembly by talin and kindlin: A dynamic view.
Zhu et al. (2021)
6 more

1 mention without citation

Structure basis of the FERM domain of kindlin-3 in supporting integrin αIIbβ3 activation in platelets.
Sun et al. (2020)