› 6vad

Electron Microscopy
3.3Å resolution

Fanconi Anemia ID complex

Released:
DOI: 10.2210/pdb6vad/pdb
PDB entry 6vad coloured by chain, front view.
PDB entry 6vad coloured by chain, side view.
PDB entry 6vad coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
DNA clamp function of the monoubiquitinated Fanconi anaemia ID complex.
Wang R, Wang S, Dhar A, Peralta C, Pavletich NP
Nature 580 278-282 (2020)
PMID: 32269332
Related structures: EMD-21137

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189811 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Fanconi anemia group I protein Chain: A
Molecule details ›
Chain: A
Length: 1328 amino acids
Theoretical weight: 149.57 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9NVI1 (Residues: 1-1328; Coverage: 100%)
Gene names: FANCI, KIAA1794
Sequence domains:
Fanconi anemia group D2 protein Chain: B
Molecule details ›
Chain: B
Length: 1451 amino acids
Theoretical weight: 164.31 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9BXW9 (Residues: 1-1451; Coverage: 100%)
Gene names: FACD, FANCD2
Sequence domains: Fanconi anaemia protein FancD2 nuclease

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-21137
Expression system: Spodoptera frugiperda

Quick links

Citations

12 review citations

Fanconi anemia: current insights regarding epidemiology, cancer, and DNA repair.
Peake et al. (2022)
11 more

3 mentions without citation

Structural insight into FANCI-FANCD2 monoubiquitination.
Li et al. (2020)
2 more