› 6vb5

X-ray diffraction
2.15Å resolution

HLA-B*15:02 complexed with a synthetic peptide

Released:
DOI: 10.2210/pdb6vb5/pdb
PDB entry 6vb5 coloured by chain, front view.
PDB entry 6vb5 coloured by chain, side view.
PDB entry 6vb5 coloured by chain, top view.
Source organisms:
Entry authors: Schutte RJ, Li D, Ostrov DA

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-123508 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ig-like domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 276 amino acids
Theoretical weight: 31.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: F4NBQ8 (Residues: 25-300; Coverage: 88%)
Gene name: HLA-B
Sequence domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 99 amino acids
Theoretical weight: 11.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-118; Coverage: 99%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Synthetic peptide THR-VAL-ARG-ALA-SER-GLY-HIS-SER-TYR Chain: C
Molecule details ›
Chain: C
Length: 9 amino acids
Theoretical weight: 979 Da
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

4 bound ligands:
Ligand ACT 2 x ACT
Ligand GOL 1 x GOL
Ligand EDO 3 x EDO
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS-II BEAMLINE 17-ID-2
Spacegroup: P212121
Unit cell:
a: 50.825Å b: 81.277Å c: 109.43Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.174 0.171 0.224
Expression systems:
  • Escherichia coli
  • Not provided

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