› 6vbh

X-ray diffraction
2Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-131674 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DNA excision repair protein ERCC-5; Flap endonuclease 1 Chain: A
Molecule details ›
Chain: A
Length: 346 amino acids
Theoretical weight: 40.12 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: O93634 (Residues: 12-128; Coverage: 33%)
  • Canonical: P28715 (Residues: 766-987; Coverage: 19%)
Gene names: ERCC5, ERCM2, PF1414, XPG, XPGC, fen, fen-1
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand SO4 15 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 12.3.1, SSRL BEAMLINE BL11-1
Spacegroup: C2221
Unit cell:
a: 64.438Å b: 173.403Å c: 101.608Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.22 0.244
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Envisioning how the prototypic molecular machine TFIIH functions in transcription initiation and DNA repair.
Tsutakawa et al. (2020)
7 more

2 mentions without citation

Human XPG nuclease structure, assembly, and activities with insights for neurodegeneration and cancer from pathogenic mutations.
Tsutakawa et al. (2020)
1 more