› 6veo

X-ray diffraction
2.4Å resolution

ATAD2B bromodomain in complex with 4-({[(3R,4R)-4-{[3-methyl-5-(5-methylpyridin-3-yl)-2-oxo-1,2-dihydro-1,7-naphthyridin-8-yl]amino}piperidin-3-yl]oxy}methyl)-1lambda~6~-thiane-1,1-dione (compound 38)

Released:
DOI: 10.2210/pdb6veo/pdb
Model geometry
Data not analysed
Fit model/data
Data not analysed
PDB entry 6veo coloured by chain, front view.
PDB entry 6veo coloured by chain, side view.
PDB entry 6veo coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Insights into the Recognition of Mono- and Diacetylated Histones by the ATAD2B Bromodomain.
Lloyd JT, McLaughlin K, Lubula MY, Gay JC, Dest A, Gao C, Phillips M, Tonelli M, Cornilescu G, Marunde MR, Evans CM, Boyson SP, Carlson S, Keogh MC, Markley JL, Frietze S, Glass KC
J Med Chem 63 12799-12813 (2020)
PMID: 33084328

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193921 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ATPase family AAA domain-containing protein 2B Chain: A
Molecule details ›
Chain: A
Length: 136 amino acids
Theoretical weight: 15.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9ULI0 (Residues: 953-1085; Coverage: 9%)
Gene names: ATAD2B, KIAA1240
Sequence domains: Bromodomain

Ligands and Environments

2 bound ligands:
Ligand SO4 2 x SO4
Ligand YD4 1 x YD4
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: BRUKER D8 QUEST
Spacegroup: P6122
Unit cell:
a: 76.358Å b: 76.358Å c: 102.312Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.196 0.194 0.251
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Functional Roles of Bromodomain Proteins in Cancer.
Boyson et al. (2021)
4 other articles

1 mention without citation

Structural Insights into the Recognition of Mono- and Diacetylated Histones by the ATAD2B Bromodomain.
Lloyd et al. (2020)