› 6vg3

X-ray diffraction
1.95Å resolution

Structure of unliganded, inactive PTK7 kinase domain

Released:
DOI: 10.2210/pdb6vg3/pdb
PDB entry 6vg3 coloured by chain, front view.
PDB entry 6vg3 coloured by chain, side view.
PDB entry 6vg3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into receptor tyrosine kinase pseudokinase function
Sheetz JB, Mathea S, Karvonen H, Malhotra K, Chaterjee D, Perttila R, Niininen W, Stayrook SE, Radhakrishnan R, Ungureanu D, Knapp S, Lemmon MA
Mol. Cell (2020)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171634 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inactive tyrosine-protein kinase 7 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 296 amino acids
Theoretical weight: 33.28 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q13308 (Residues: 774-1069; Coverage: 29%)
Gene names: CCK4, PTK7
Sequence domains: Protein tyrosine and serine/threonine kinase

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: C2221
Unit cell:
a: 95.628Å b: 119.918Å c: 166.516Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.189 0.244
Expression system: Spodoptera frugiperda

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