› 6vgo

X-ray diffraction
1.82Å resolution

Crystal Structure of Human Dipeptidase 3

Released:
DOI: 10.2210/pdb6vgo/pdb
PDB entry 6vgo coloured by chain, front view.
PDB entry 6vgo coloured by chain, side view.
PDB entry 6vgo coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of human DPEP3 in complex with the SC-003 antibody Fab fragment reveals basis for lack of dipeptidase activity.
Hayashi K, Longenecker KL, Koenig P, Prashar A, Hampl J, Stoll V, Vivona S
J Struct Biol 211 107512 (2020)
PMID: 32325220

Function and Biology Details

Reaction catalysed: 
Hydrolysis of dipeptides.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190609 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dipeptidase 3 Chain: A
Molecule details ›
Chain: A
Length: 488 amino acids
Theoretical weight: 53.75 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q9H4B8 (Residues: 1-488; Coverage: 100%)
Gene names: DPEP3, UNQ834/PRO1772
Sequence domains: Membrane dipeptidase (Peptidase family M19)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P43212
Unit cell:
a: 65.88Å b: 65.88Å c: 194.31Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.186 0.214
Expression system: Cricetulus griseus

Quick links

Citations

1 review citation

Antibody-Antineoplastic Conjugates in Gynecological Malignancies: Current Status and Future Perspectives.
Martín-Sabroso et al. (2021)
1 other article