6vi0

Electron Microscopy
3.43Å resolution

Cryo-EM structure of VRC01.23 in complex with HIV-1 Env BG505 DS.SOSIP

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dodecamer (preferred)
PDBe Complex ID:
PDB-CPX-212161 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (10 distinct):
Transmembrane protein gp41 Chains: A, B, F
Molecule details ›
Chains: A, B, F
Length: 153 amino acids
Theoretical weight: 17.15 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q2N0S6 (Residues: 509-661; Coverage: 18%)
Gene name: env
Sequence domains: Retroviral envelope protein
Envelope glycoprotein gp160 Chains: C, G, I
Molecule details ›
Chains: C, G, I
Length: 481 amino acids
Theoretical weight: 54.09 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q2N0S6 (Residues: 30-508; Coverage: 56%)
Gene name: env
Sequence domains: Envelope glycoprotein GP120
VRC01.23 Light chain Chains: D, J, L
Molecule details ›
Chains: D, J, L
Length: 207 amino acids
Theoretical weight: 22.76 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
VRC01.23 Heavy chain Chains: E, H, K
Molecule details ›
Chains: E, H, K
Length: 229 amino acids
Theoretical weight: 25.11 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.43Å
Relevant EMDB volumes: EMD-21208
Expression system: Homo sapiens