› 6vl8

X-ray diffraction
2.42Å resolution

Anti-PEG antibody 6-3 Fab fragment in complex with PEG

Released:
DOI: 10.2210/pdb6vl8/pdb
PDB entry 6vl8 coloured by chain, front view.
PDB entry 6vl8 coloured by chain, side view.
PDB entry 6vl8 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structure of an anti-PEG antibody reveals an open ring that captures highly flexible PEG polymers
Huckaby JT, Jacobs TM, Li Z, Perna RJ, Wang A, Nicely NI, Lai SK
Commun Chem 3 124- (2020)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-232273 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
6-3 Fab heavy chain Chains: A, C, E, H
Molecule details ›
Chains: A, C, E, H
Length: 228 amino acids
Theoretical weight: 24.74 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
6-3 Fab light chain Chains: B, D, F, L
Molecule details ›
Chains: B, D, F, L
Length: 219 amino acids
Theoretical weight: 24.07 KDa
Source organism: Mus musculus
Expression system: Homo sapiens

Ligands and Environments

2 bound ligands:
Ligand EDO 3 x EDO
Ligand PEU 2 x PEU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 112.108Å b: 87.791Å c: 116.074Å
α: 90° β: 113.655° γ: 90°
R-values:
R R work R free
0.186 0.184 0.24
Expression system: Homo sapiens

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