› 6vpq

X-ray diffraction
1.74Å resolution

Crystal structure of the C-terminal domain of DENR

Released:
DOI: 10.2210/pdb6vpq/pdb
PDB entry 6vpq coloured by chain, front view.
PDB entry 6vpq coloured by chain, side view.
PDB entry 6vpq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the C-terminal domain of DENR.
Lomakin IB, De S, Wang J, Borkar AN, Steitz TA
Comput Struct Biotechnol J 18 696-704 (2020)
PMID: 32257053

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129009 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Density-regulated protein Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 198 amino acids
Theoretical weight: 22.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O43583 (Residues: 1-198; Coverage: 100%)
Gene names: DENR, DRP1, H14
Sequence domains:

Ligands and Environments

4 bound ligands:
Ligand MG 23 x MG
Ligand PGE 11 x PGE
Ligand ACT 3 x ACT
Ligand CA 3 x CA
1 modified residue:
Ligand CSO 6 x CSO

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P21
Unit cell:
a: 64.67Å b: 47.26Å c: 95.5Å
α: 90° β: 106.29° γ: 90°
R-values:
R R work R free
0.181 0.178 0.247
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 citation in other articles

DENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion.
Chen et al. (2022)
1 more

1 mention without citation

Crystal structure of the C-terminal domain of DENR.
Lomakin et al. (2020)