› 6vsv

X-ray diffraction
1.62Å resolution

Crystal structure of a disease mutant of the Voltage-gated Sodium Channel Beta 4 subunit extracellular domain

Released:
DOI: 10.2210/pdb6vsv/pdb
PDB entry 6vsv coloured by chain, front view.
PDB entry 6vsv coloured by chain, side view.
PDB entry 6vsv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Biophysical Investigation of Sodium Channel Interaction with β-Subunit Variants Associated with Arrhythmias.
Llongueras JP, Das S, De Waele J, Capulzini L, Sorgente A, Van Petegem F, Bosmans F
Bioelectricity 2 269-278 (2020)
PMID: 34476357

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184891 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sodium channel subunit beta-4 Chain: A
Molecule details ›
Chain: A
Length: 129 amino acids
Theoretical weight: 14.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IWT1 (Residues: 32-157; Coverage: 64%)
Gene name: SCN4B
Sequence domains: Immunoglobulin V-set domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P3221
Unit cell:
a: 43.123Å b: 43.123Å c: 107.492Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.186 0.185 0.208
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Late Sodium Current of the Heart: Where Do We Stand and Where Are We Going?
Horváth et al. (2022)

1 mention without citation

Biophysical Investigation of Sodium Channel Interaction with β-Subunit Variants Associated with Arrhythmias.
Llongueras et al. (2020)