› 6vtm

X-ray diffraction
1.6Å resolution

Human Cathepsin-G Inhibited by S. aureus EapH1

Released:
DOI: 10.2210/pdb6vtm/pdb
PDB entry 6vtm coloured by chain, front view.
PDB entry 6vtm coloured by chain, side view.
PDB entry 6vtm coloured by chain, top view.
Source organisms:
Primary publication:
Crystal Structure of Human Cathepsin-G Inhibited by S. aureus EapH1
Herdendorf TJ, Rooijakkers SHM, Geisbrecht BV
J. Biol. Chem. (2020)

Function and Biology Details

Reaction catalysed: 
Specificity similar to chymotrypsin C.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-102022 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cathepsin G Chains: A, C, D, G
Molecule details ›
Chains: A, C, D, G
Length: 224 amino acids
Theoretical weight: 25.48 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P08311 (Residues: 21-244; Coverage: 95%)
Gene name: CTSG
Sequence domains: Trypsin
MAP domain-containing protein Chains: B, E, F, H
Molecule details ›
Chains: B, E, F, H
Length: 99 amino acids
Theoretical weight: 11.11 KDa
Source organism: Staphylococcus aureus subsp. aureus Mu50
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A0A0H3K0M1 (Residues: 43-141; Coverage: 89%)
Gene name: SAV2205
Sequence domains: MAP domain

Ligands and Environments

1 bound ligand:
Ligand SO4 13 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P1
Unit cell:
a: 59.229Å b: 72.902Å c: 88.906Å
α: 113.58° β: 91.17° γ: 106.24°
R-values:
R R work R free
0.175 0.174 0.209
Expression system: Escherichia coli BL21(DE3)

Quick links